ABSTRACT. Background: The dengue and chikungunya epidemics have major challenging problems and have become essentially a public health importance. The Chikungunya virus was isolated from mosquitoes and found to be identical to the AV circulating human strain. This is the first field study. Mosquitoes transmit numerous arboviruses including dengue and chikungunya virus (CHIKV). Chikungunya is a re-emerging arthropod-borne.
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Manifestasi Klinis Infeksi Virus Chikungunya Pada Kejadian Luar Biasa Di Indonesia – Neliti
Email this article Login required. Goupil 1 and Christopher N. Clinical progression of chikungunya fever during acute and chronic arthritic stages and the changes in joint morphology as revealed by imaging.
Currently, in all available reports, pre-existing joint disease or development of an unrelated joint disease such as OA or RA cannot be ruled out.
The most joint pain chikunbunya reported is wristand knee joints Other similarities in laboratory results shared by CHIKV and RA include variably elevated erythrocyte sedimentation rates, elevated C-reactive protein, and presence of anti-citrullinated protein antibodies [ 9203135384047 ]. Ribavirin therapy for Chikungunya arthritis. It is essential that thorough clinical workups of patients during acute stages be performed to evaluate for existing disease.
Chikungunya fever in Canada: In fact, CHIKV-induced arthritis has been compared to RA in regard to some of the pathologic changes, and studies have indicated that radiographs of RA patients are often normal for months after the initial symptoms arise, while erosions can be demonstrated by MRI less than 6 months after symptom onset [ 54 ].
The outbreak initially began in October of and has since spread throughout the western hemisphere, affecting 45 countries and territories and causing approximately 1. In most instances, these parameters will return to normal in the second week of infection [ 25 ], though a persistent lymphopenia 36 months after the initial infection has been rarely reported [ 30 ].
While many have shown promise in animal models as demonstrated by production of neutralizing antibodies and protection against viral challenge, few have moved into clinical trials.
The VLPs for one of these are produced in HEKT cells and results of a phase I dose escalation trial have been reported, demonstrating significant production of neutralizing antibodies and no severe adverse responses [ 6566 ]. In cases refractory to NSAID treatment, short-term courses of corticosteroids have been attempted with variable success.
While corticosteroid treatments are usually not recommended due to the potential for a severe rebound of arthritis and tenosynovitis after therapy is ended, in severe cases of inflammatory polyarthritis refractory to NSAID treatment, the benefits may outweigh the risks [ 61 ].
Additionally, pre-existing joint disease present at the time of initial infection and development of joint disease such as OA or RA unrelated to CHIKV infection cannot be ruled out. The acute phase of Chikungunya virus infection in humans is associated with strong innate immunity and T CD8 cell activation. The purpose of this review is to evaluate the literature and summarize the current state of knowledge regarding CHIKV-associated disease, including clinical presentation, diagnosis, risk factors for development of severe disease, treatment, and pathogenesis in human patients.
Blood chemistry results are often normal throughout the disease course, though increased liver enzymes including ALT and AST have been reported [ 925 ].
In some cases, MRI demonstrated clear improvement in severity of joint swelling, and pain and tendon involvement continuing for 15 months after initiation [ 41 ]. While animal models have been useful to study acute joint disease demonstrating evidence for viral persistence, no models exist for development of chronic joint disease associated with CHIKV infection.
Manifestasi Klinis Infeksi Virus Chikungunya Pada Kejadian Luar Biasa Di Indonesia
Inflammatory cytokine expression is associated with chikungunya virus resolution and symptom severity. Suspected Chikungunya are interviewed and taken blood.
However, Bouquillard et al. The case numbers decreased inresulting in a total of chikunguhya of CHIKV-induced disease and 1 locally acquired case in Texas [ 8 ].
Additionally, it is possible that some patients develop joint disease such as osteoarthritis or rheumatoid arthritis, completely unrelated to the previous CHIKV infection. If received prior to infection, viremia and virus levels in ankles were decreased to below the level of detection, however, when administered after infection, though viremia decreased, there were no effects on the levels of viral RNA in the inoculated foot [ 4 ].
Chikungunya is a re-emerging disease that caused byalphavirus family Togaviridae. Serological assays for detection of anti-CHIKV IgM or IgG can be performed during the first few weeks or months, respectively, though false negative results can occur depending on the stage of disease [ 46 ]. Jurnal Biotek Medisiana Indonesia terbit 2 kali dalam 1 tahun, merupakan media informasi hasil pe Chikungunya Virus, final data ujrnal the United States.
It should also be noted that aspirin is not recommended due to bleeding risk [ 12 ]. Unfortunately, efficacy data for most treatment regimens are lacking [ 26 ].
Assessment of the extent of the acute lesions such as joint effusion, synovitis, tendinitis, enthesopathy or bone marrow edema may make it possible to identify people with more severe disease, potentially aiding in the choice of treatment strategies for those at greater risk for developing chronic or relapsing disease.
However, potential causes of chronic CHIKV-induced arthritis have been postulated, including viral persistence, induction of autoimmune disease, and exacerbation of pre-existing joint disease [ 423 ]. Effectiveness of chloroquine and inflammatory cytokine response in patients with early persistent musculoskeletal pain and arthritis following chikungunya virus infection.
In this study, Explosive re-emergence of chikungunya fever has been started since and affected millions people in worldwide i.